CALL FOR PAPERS Cardiovascular-Renal Mechanisms in Health and Disease The elevated blood pressure of human GRK4 A142V transgenic mice is not associated with increased ROS production
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چکیده
Zheng Wang, Ines Armando, Laureano D. Asico, Crisanto Escano, Xiaoyan Wang, Quansheng Lu, Robin A. Felder, Christine G. Schnackenberg, David R. Sibley, Gilbert M. Eisner, and Pedro A. Jose Department of Pediatrics and Physiology and Biophysics, Georgetown University School of Medicine, Washington, District of Columbia; Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, Virginia; Department of Investigative and Cardiac Biology, GlaxoSmithKline, King of Prussia, Pennsylvania; Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, Maryland; and Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia
منابع مشابه
The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production.
G protein-coupled receptor (GPCR) kinases (GRKs) regulate the sensitivity of GPCRs, including dopamine receptors. The GRK4 locus is linked to, and some of its polymorphisms are associated with, human essential hypertension. Transgenic mice overexpressing human (h) GRK4gamma A142V on a mixed genetic background (C57BL/6J and SJL/J) have impaired renal D(1)-dopamine receptor (D(1)R) function and i...
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G protein-coupled receptor kinases (GRKs) are important regulatory proteins for many G protein-coupled receptors, but little is known about GRK4 pharmacogenetics. We hypothesized that 3 nonsynonymous GRK4 single-nucleotide polymorphisms, R65L (rs2960306), A142V (rs1024323), and A486V (rs1801058), would be associated with blood pressure response to atenolol, but not hydrochlorothiazide, and woul...
متن کاملG-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions.
BACKGROUND African Americans have a disproportionate burden of hypertension and comorbid disease. Pharmacogenetic markers of blood pressure response have yet to be defined clearly. This study explores the association between G-protein-coupled receptor kinase type 4 (GRK4) variants and blood pressure response to metoprolol among African Americans with early hypertensive nephrosclerosis. METHOD...
متن کاملRelationship between some indices of cardiovascular functions and pulse pressure as a predictor index for heart diseases: a case-control study
Background: Pulse pressure has recently been considered as a predictor of coronary heart disease. The difference between systolic and diastolic blood pressure is called pulse pressure. Various factors including increased age, vascular stiffness, stenosis, and hypertension are associated with pulse pressure. The present study, therefore, aimed to investigate the relationship between some cardiov...
متن کاملSingle-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension.
BACKGROUND Salt-sensitive (SS) hypertension affects >30 million Americans and is often associated with low plasma renin activity. We tested the diagnostic validity of several candidate genes for SS and low-renin hypertension. METHODS In Japanese patients with newly diagnosed, untreated hypertension (n = 184), we studied polymorphisms in 10 genes, including G protein-coupled receptor kinase ty...
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تاریخ انتشار 2007